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What Does Zinc Have to Do With BPH, Cancer and Other Prostate Disease?
Did you know that more than 60% of American men are zinc deficient? Male sperm has 100 times more zinc than blood! Here’s another fact: You may have read somewhere that DHT (dihydrotestosterone) causes prostate enlargement.
WAIT! Maybe I’m getting ahead of myself, let’s start again.
- The prostate gland is very unusual because it undergoes an increase in size at several stages during most of a man’s life.
- The first phase of growth ends before or at birth, when the average prostate weighs about 1.5 grams.
- The second phase of growth occurs early in puberty, when the weight of the prostate gland increases to about 11 grams.
- The third growth phase occurs in the mid-20s, when the weight of the prostate gland increases to approximately 18 grams.
- The second stage that begins when a man is in his 50s. The size varies depending on the health of the man.
- By the time a man is in his 70s, the prostate gland has reached a maximum weight of 31 grams.
There is another glaring flaw
Although the prostate gland grows throughout most of a man’s life, urinary flow problems Benign prostatic hypertrophy (BPH) and/or cancer usually do not appear until after the age of 50 as a result of the final phase of growth.
Medical researchers do not yet know why the prostate gland enlarges during multiple growths. However, there are two theories that try to explain this phenomenon. Both theories believe that hormonal changes over time are responsible.
(1) Changes in the normal balance of sex hormones. With increasing age, the amount of the male hormone, testosterone, the main male reproductive hormone. Created in the testes, it is responsible for the growth and maturation of the male primary reproductive organs and the development of characteristics such as a low voice, the unique distribution of male body hair, a relative lack of subcutaneous fat, and greater bone structure. , decreases in relation to the amount of circulating estrogen
A female hormone that is also found in small amounts in a male’s bloodstream., the main female reproductive hormone that also circulates in the male.
There is some evidence to suggest that this relative increase in circulating estrogen may potentiate the effect of the testosterone derivative DHT, which stimulates cell growth in the prostate gland and is formed when testosterone acts on a specific enzyme. As a result of estrogen and DHT acting together, cell growth and glandular enlargement are stimulated.
NOTE: Ah-ha, DHT seems to get out of hand and may be the cause of BPH. Any wonder what exactly is DHT? Well there you go. DHT is a biologically active metabolite of the hormone testosterone, formed mainly in the prostate gland, testicles, hair follicles and adrenal glands by the enzyme 5α-reductase by reduction of the 4,5 double bond. DHT belongs to the class of compounds called androgens, commonly called androgenic hormones or testoids. Androgens are part of the biology of gender by stimulating and controlling the development and maintenance of male characteristics. DHT is 3 times more potent than testosterone; Testosterone is 5-10 times more potent than adrenal androgens.
(2) Now here is the second theory about DHT. The development of the prostate gland requires the conversion of testosterone to DHT. In the presence of a specific enzyme called 5-alpha reductase. As aging occurs, the amount of DHT in the prostate gland remains high, even through the decline in circulating testosterone levels.
Some evidence supports the idea that this high level of prostate DHT may itself stimulate cell growth and lead to enlargement.
Now after that introduction we come to zinc. The role of zinc in a wide range of cellular processes, including cell division (ah – that means getting bigger – right?) and proliferation, immune function and protection against free radicals, is well established. Zinc is the most abundant micronutrient in cells, and growing evidence points to the important role of zinc in both genetic stability and function.
Zinc deficiency can lead to immune dysfunction and impaired growth, cognitive function, and hormonal function. Over 2 billion people worldwide may be zinc deficient, you don’t have to be one of them.
Research has established a link between zinc deficiency and cancer has now been established by human, animal and cell culture studies. We also know that zinc status is compromised in cancer patients compared to healthy people.
Zinc also appears to play an important role in maintaining prostate health. Prostate cancer is the second leading cause of cancer death in American men, and most older men have some abnormal prostate cells. BPH may or may not be a precursor to prostate cancer. The normal human prostate accumulates the highest level of zinc of any soft tissue in the body, but we don’t know why. However, cancerous prostates have much less zinc than normal prostates, and several studies have implicated impaired zinc status in the development and progression of prostate malignancy. There is also some evidence that increased dietary zinc is associated with a decreased incidence of prostate cancer.
Zinc supplementation strategies can not only help prevent cancer, but also play an important role in limiting its malignancy. As an antioxidant and a component of many DNA repair proteins, zinc plays an important role in protecting DNA from damage. The current tolerable upper intake level for zinc is 40 mg/day, set by the American Institute of Medicine. Thus, it is possible that the subjects in the epidemiologic study were in the toxic range of zinc intake. As with most therapies, higher doses do not always equate to an increase in
As a final note, zinc has several positive side effects such as: effective in shortening cold symptoms, reducing the severity of colds, increasing energy levels, treating ADHD in children, fighting hair loss, and managing conditions such as hypoglycemia and diabetes. The negative side effect of zine can include: Decreased levels of copper, iron and magnesium, decreased immune function of your body and decreased level of HDL (good cholesterol). Additional rare side effects may include: stomach upset, heartburn and nausea, fever, sore throat, mouth sores, weakness and fatigue.
There is some hope in clinical trials. Irving Bush, MD, professor of urology at the University of Health Sciences/Chicago School of Medicine, senior consultant at the Center for the Study of Genitourinary Disease in West Dundee, Illinois, and former chairman of the Food and Drug Administration’s panels on gastroenterology, urology and dialysis, did a small study of the use of zinc in the treatment of BPH. The men in the study received 150 milligrams of inc sulfate daily for two months, followed by 50 to 100 milligrams daily as a maintenance dose. Dr. Bush found that 14 of the 19 men experienced prostate shrinkage.
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#Zinc #BPH #Cancer #Prostate #Disease